Flexcell^® Tension System (FX-6000T)

• Apply equibiaxial or uniaxial tension to cells in 2D and 3D culture.
• Simulate in vivo tissue strains and frequencies in an in vitro setting.
• Uses regulated vacuum pressure and positive air pressure to deform flexible-bottomed culture plates.
• Contains state-of-the-art digital valve to automatically regulate and maintain pressure for a specified strain regimen.
• Multiple frequency, amplitude, and waveform changes can be programmed in one regimen.
• Drives up to four independent FlexLink^® remote compression and/or tension controllers.

Flex Jr. Tension System

• Apply equibiaxial or uniaxial tension to cells in Flexcell's^® microscopy devices (microscopy devices sold separately).
• Computerized, vacuum-operated system that applies a defined controlled, static or variable duraction cyclic tension to cells in the microscopy devices StagerFlexer^®, StageFlexer Jr.^® and Flex Flow™.
• NEW! System now works with Single Plate Baseplate Kits (SPBK-1000).

Flexcell^® Tissue Train^® System (FX-6000TT)

• 3D cell culture in a gel matrix with or without cyclic uniaxial tension.
• Stand-alone culture system to create 3D geometries for cell culture in a matrix gel or allows the cells to build a self-assembled matrix that connects to the anchors in a Tissue Train^® culture plate.
• Utilizes regulated vacuum to deform cells cultured on flexible-bottomed culture plates.
• Simulate in vivo tissue strains and frequencies in cells from muscle, lung, heart, blood vessels, skin, tendon, ligament, cartilage, and bone.

Flexcell^® Compression System (FX-5000C)

• Apply cyclic or static compression to cells in 3D culture.
• Computerized, pressure-operated instrument that applies a defined controlled, static or variable duration cyclic compression to cells growing in vitro.
• Utilizes regulated air pressure to deflect flexible-bottomed BioPress™ culture plates compressing a tissue sample or a 3D culture between a piston and a stationary platen.
• Simulate in vivo tissue forces and frequencies in cells from muscle, lung, heart, blood vessels, skin, tendon, ligament, cartilage, and bone.

Streamer^® Shear Stress Device (STR-4000)

• Apply fluid shear stress to cells with laminar, pulsatile or oscillating flow.
• Parallel plate flow system to investigate fluid-induced shear stress to cells grown in a monolayer.
• Includes a six-chamber laminar flow device and can be used to apply laminar, pulsatile*, or oscillating* flow to cells cultured on special matrix coated PTFE rimmed culture slips^®. (*if used with Osci-Flow® , see below)
• Regulation of shear stress from 0 - 35 dynes/cm² by computer controlled peristaltic pump.

FlexLink^® for Tension or Compression (FX-6000TFL and FX-5000CFL)

• Upgrade your existing FX-6000T or FX-5000C with a second controller that links with an FX-6000™ system computer allowing the user to simultaneously operate two different regimens on two different baseplates.
• Expand the application area of your FX-6000T system with the possibility to apply Compression tests by adding a Compression FlexLink^® FX-5000CFL.
• Expand the application area of your FX-5000C system with the possibility to apply Tension tests by adding a Tension FlexLink^® FX-6000TFL.

Flexcell^® Baseplate Kits

Expand the application areas of your Tension or Tissue Train^® Systems

Following Baseplate Kits are available:

• BioFlex^® Baseplate Kit to apply equibiaxial strain to 2D cell cultures (using the BioFlex^® culture plates) or to 3D constructs (using the Tissue Train^® Circular Foam culture plates).
• Tissue Train^® Baseplate Kit to apply uniaxial strain to 3D cell cultures in Tissue Train^® culture plates or to monolayer cell cultures in UniFlex^® culture plates.
• UniFlex^® Baseplate Kit to apply uniaxial strain to cells cultured in monolayer in UniFlex^® culture plates.
• 24-Well HT Baseplate Kit for high throughput strain tests of cells cultured in Flexcell's^® 24-well HT BioFlex^® culture plates, with Cell Seeders™ to place cells in the central region of the wells.

Transwell^® Holder

Transwell^® is a registered trademark of Corning^® Inc.

• Holds Transwells^® to allow for cell migration and co-culture assays to be performed in Flexcell® culture plates.
• Analyze cell migration in response to strain.
• Available for 6- and 24-well Flexcell^® culture plates.
• Compatible with standard Transwell^® sizes for 6-well and 24-well culture plates.

BioFlex^® Cell Seeders (BFCS-1000 / BFCS-4000)

• Provide an optimization of the biomechanical test.
• Confine cells during plating and adhesion to the central area of the wells in a BioFlex^® culture plate.
• Prevent the growth of the cells at the edges of the wells resulting in a well defined equibiaxial strain of all seeded cells.
• Handling is user-friendly and a Flexcell^® Tension System can be upgraded easily with this new accessory.

FlexStop™ (BFS-3000)

• Use a FlexStop™ to block stretching.
• Reusable valved rubber stopper that inserts into the underside of a BioFlex^® culture plate well to prevent vacuum-induced deformation.
• Provides a convenient negative control when testing mechanical load effects on cells in the same BioFlex^® culture plate.
• Designed to work in conjunction with the BioFlex^® culture plates and BioFlex^® Loading Stations™.
• Also works with Tissue Train^® and UniFlex^® culture plates.

Osci-Flow^® Flow Controller (STR-4000-OFS)

• Provides regulated oscillatory and pulsatile flow control via computer controlled action.
• Minimizes flow response lag by eliminating inertial effects of decelerating and accelerating pumps and motors.
• Reverses fluid flow instantaneously.
• Works with Streamer^® and FlexFlow™ shear stress devices.
• Adapts to other perfusion systems.

StageFlexer^® Microscopy Device (SF-3000)

• A single-well embodiment of a BioFlex^® culture plate well designed to strain cells in monolayer while observing the cellular activity with an upright microscope in real-time.
• Device can be used with Flexcell's^® Tension, Tissue Train^®, or Flex Jr. Tension systems that allow the control of strain frequency, amplitude, waveform, and cycles
  (or time period).

StageFlexer^® Jr. Microscopy Device (SF-4000)

• Microscopy device for membranes removed from BioFlex^®, UniFlex^®, or Tissue Train^® plates.
• Designed to strain cells in monolayer while observing the cellular activity with an upright microscope in real-time.
• Device can be used with Flexcell's^® Tension, Tissue Train^®, or Flex Jr. Tension systems that allow the control of strain frequency, amplitude, waveform, and cycles
  (or time period).

NEW! Inverted "StageFlexer I^®" Microscopy Device (ISF-5000)

• Observe cells strechting in real-time with either an upright or inverted microscope.
• Compatible with the FX-5000™, FX-6000™ and Flex Jr.™ Tension Systems.
• Membrane stretch ranges from 1,6 % up to 12 %
• Easy set-up und use.

StagePresser™ Microscopy Device (SP-3000)

• A single-well embodiment of the Compression apparatus designed to compress a single tissue sample or cells in a 3D culture while viewing the cellular activity under an upright microscope.
• Works with the Compression System.

ScanFlex™ Scanning Device

• Automated scanning device with area measurement software XyFlex™.
• Can be used in conjunction with the Tissue Train^® system to determine the compaction kinetics (change in area) of 3D cell seeded-gels.
• Scans four 6-well or 24-well Flexcell^® culture plates.
• Measures gel compaction in 3D bioartificial tissues.
• Automated repetitive scanning process.

FlexFlow™ Shear Stress Device (FF-3000)

• Parallel plate laminar flow device designed to apply fluid shear stress and/or cyclic strain to cells in culture while providing a means for viewing cell activity under an upright microscope in real-time.
• Strain cells using the Flexcell's^® Tension, Tissue Train^®, or Flex Jr. Tension systems before, during or after applying shear stress.
• Uses a computer controlled peristaltic pump to regulate shear stress from 0 - 35 dynes/cm².