Liquid Handling Systems for High-Throughput Applications, Drug Research,
Genomic Solutions and Protein Crystallography

 

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“Scorpion” high-speed dispenser / screen builder

The “Scorpion” is an innovative high-speed single-channel robotic platform. This extremely versatile work station can be used to perform everything that can be done with hand-held pipettes, but with the speed and precision of an automated dispenser. Furthermore, it is useful for the preparation and reformatting of screening kits for crystallographic applications, including set-up of 24-well optimization plates.

 

Features:

  • Compatible with 50 µl, 200 µl, and 1000 µl pipette tips with dispensing down to 0.5 µl
  • Multiple tip sizes can be used in one protocol
  • Dispense data can be defined as volume, concentration or pH
  • Deck will accommodate a choice of 6 SBS-format plates, such as 96 racked 15 ml tubes, a deep well block and a rack of pipette tips for setting up plates from 15 ml tubes
  • Tip head design allows pipette tips to reach to the bottom of tall tubes such as 15 ml and 50 ml tubes and deep well blocks
  • Re-array screens from 15 ml tubes into 96-well plates
  • Movement velocity of 2 meters / sec. with extreme accuracy
  • Intelligent motion control software optimizes dispense paths and volumes
  • Liquid level sensing allows the tip to follow liquid levels improving aspirate and dispense accuracies
  • Easily build complex optimization grids
  • Easy set-up of user-defined and gradient screen plates
  • Positive air displacement pipette head and optimized dispense modes make it easy to work with a wide range of fluid viscosities, such as DMSO, 50 % PEG 20.000, and 80 % Glycerol
  • Can be used in a cold room or up to 70 °C, non-condensing
  • Small footprint (w x d x h) 48.3 x 48.3 x 69.8 cm
  • Desktop computer with multi-slot software licence
  • Emergency stop button 
 

 

 

"Gryphon" – Modular Microdispenser System

The “Gryphon” is a compact modular dispenser. Due to the use of flexible and long-lasting Nitinol needles the “Gryphon” is an environmentally friendly liquid handling system without follow-on cost for disposables. For protein crystallography the "Gryphon" is available in three configurations: "Crystal Gryphon", "Gryphon LCP", and "Crystal Gryphon LCP". A basic "Gryphon" is also available as standard dispenser with 96-syringe head.

 

Features:

  • No disposables, cutting operating costs
  • The “All-In-One” Microdispenser enables screen and protein drop setting in one protocol
  • Modular design allows for custom set-ups to meet needs of application
  • 96-heads with flexible needles with 100, 250, 500 or 1000 µl volume options
  • 24-head and 384-head options available
  • Up to 4 protein source positions
  • Flex syringe dispense head for dispensing down to 100 nl (CV < 5 %)
  • 2 position X-Y stage
  • Integrated wash system
  • Easy to use drag-and-drop software
  • Optional nano-dispense module
  • Small space-saving footprint (h x w x d): 51 x 59 x 59 cm
  • LCP (Lipidic Cubic Phase) module ("Gryphon LCP"):
    - 25 nl of viscous solutions with a CV of < 5 % in less than 90 seconds
    - Self-aligning syringe needle and integrated LCP mixer
    - Aspirate directly from screen blocks
    - 96-well sandwich plate ready to seal in less than 2 minutes
    - 8 tube positions for seeding applications
     
  • Non-contact Nano dispenser module ("Crystal Gryphon")
    - For protein aspiration and dispensing 50 nl up to 100 µl
    - For on-the-fly dispense of water soluble proteins
    - For set-up of sitting drop, hanging drop, and microbatch reactions
    - Gradient dispensing possible
     
  • The largest variety of applications offer the "Crystal Gryphon LCP" combining the features of the LCP- and Nano-dispenser modules.
 

 

 

"Phoenix" Microdispenser

The “Phoenix” is a multiposition, high-throughput liquid-handling platform that incorporates a space-saving design with flexible dispensing options. The “Phoenix” uses an innovative syringe and needle technology therefore avoiding follow-on costs for disposable tips. This unique instrument combines the precise low-volume dispensing capabilities of a syringe head with a non-contact nano-dispenser.

 

Features:

  • No disposables, cutting operating costs
  • Set-up sitting drops, hanging drops, and microbatch reactions
  • Nine assay positions: 6 source or destination plate positions, 2 reagent positions, 1 wash station position
  • 96- or 384-channel positive displacement syringe heads with flexible Nitrinol needles
  • Head volumes of 100, 250, 500, 1000 µl. Dispense volumes down to 100 nl with a CV < 5 %
  • Gradient dispensing possible
  • Optional non-contact nano-dispenser drive: can accommodate 1, 2, 3, or 4 channels to deliver volumes as low as 50 nl with a CV < 5 %
  • Nano dispenser can be used in aspirate/dispense or bulk dispense modes
  • Nano dispenser can dispense viscous liquids up to 30 % Glycerol or 20 % PEG4000
  • Bench-top lab use: footprint of (w x d x h) 63.5 x 68.6 x 73.6 cm
  • Windows-based drag-and-drop software
  • Closed-loop motion control on each axis: verification of task completion via encoders on each motor
  • Integrated wash-system
 

 

 

"Cobra" - 1 or 4 Channel Nano Dispenser

The “Cobra” line of non-contact nano-dispensers is available with 1 or 4 channels and dispense volumes ranging from 300 nl to 5 ml. It allows fast on-the-fly dispensing which quickly fills all kind of microplates. The “Cobra” can be used in aspirate/dispense mode or bulk dispense mode. It is ideal as PCR tool, requires only little space, and allowing low volume reactions saves expensive reagents.

 

Features:

  • Ideal for PCR master mix dispensing
  • Dispense 300 nl to 5 ml using 1 or 4 non-contact nano-dispensers
  • 1- and 4-channel aspirate / dispense mode
  • Dispense any volume, any well with up to 4 independent reagents
  • Dispense gradients for direct dilutions
  • Aspirate from deep well blocks and capped tubes
  • 2 plate position deck
  • Fast on-the-fly dispensing into 96-, 384-, 1536-well plates, and deep well blocks
  • Fills a 384-well plate in 35 seconds
  • Integrated wash system
  • Liquid level sensing for all reagent bottles
  • Small space-saving footprint: (w x d x h) 35.5 x 50.8 x 40.6 cm
 

 

 

 

 

 

 

 

 

 

 

 

 

"CrysCam™" and "CrysCam UV™" Digital Microscopes
for Protein Crystal and Microplate Observation and Documentation

The “CrysCamTM” Digital Microscope allows you to capture the images of an entire plate with a click of the mouse. Both digital microscopes can also be used to observe the formation of crystals during crystallization.

 

Features "CrysCam™":

  • Compatible with 96-well, 24-well and Terasaki plates
  • Can be used in a cold room at 4 °C
  • Quality par focal zoom lens with iris
  • 6x zoom with 3.87 mm x 5.16 mm - 0.6 mm x 0.8 mm field of view
  • Integrated cross polarization
  • High resolution USB camera
  • 3 Mpix CMOS camera, 1/3 inch sensor
  • Smooth large base platform with integrated LED lighting
  • Reads a 96-well plate in less than three minutes
  • Image acquisition and processing software
  • Accurate and precise closed-loop control
  • Easy-to-use Windows software
  • Predefined plate library makes choosing the right well location quick and easy

 

Features "CrysCam UV™":

  • Automatically scan the plates and capture visual and UV images
  • The instrument reads and captures all 96 visual images, then reads the plate a second time to capture all 96 UV images
  • View both visual and UV image for a specific well at the same time
  • Powered focus and zoom through the software, and the camera stays focused when zooming
  • Can flag wells of interest
  • Can view individual wells with or without a polarizer
  • User definable input of different plate formats
  • Determins crystal X-Y-Z position for use with in situ crystal diffraction
  • Currently the "CrysCam UV™" is being used to capture crystal images in nano size drops
  • Artemis VS60 camera with a resolution of 2750 x 2205 (6 MPixel)
  • Digital image of 2.37 microns/pixel with a minimum zoom to 0.7 microns/pixel
 

 

 

"LCP Mixing Station"

The LCP (lipidic cubic phase) Mixing Station is ideally suited for the preparation of viscous solutions often used for the crystallization of membrane proteins.

 

Features:

  • Accommodates different syringe types including Hamilton style and the ARI LCP dispensing syringe
  • Any volume syringe can be used provided both syringes are the same volume
  • Quick and easy to load
  • Loading the syringe automatically sets the mixing stroke so that the mix volume is equal to the sample volume in the syringe
  • Audible alarm can be set to sound off after defined elapsed time
  • Easy to clean polished stainless steel mixing chamber
  • Compact size: 34,3 x 13,9 x 11,4 cm
 

 

 

LCP Hand Held Multi Volume Dispenser

The new LCP Hand Held Dispenser can be used with syringes from different manufacturers such as Art Robbins Instruments or Hamilton.

The Hand Held Dispenser allows setting up to 200 steps and can move 1, 2 or 3 steps per click. Depending on the volume of the used syringe, you can dispense per step either 1/200, 1/100 or 3/200 of the total syringe volume.

 

 

 

 

Also available:

  1. Reconditioned Hydra and Serum Dispenser
  2. Accessories for Liquid Handling Systems
  3. Tissue Typing products
  4. Intelli-Plates for protein crystallization

     

      Additional information on request